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. 1980 Jun;28(3):753–761. doi: 10.1128/iai.28.3.753-761.1980

Human trials with wild-type H1N1 and recombinant H3N2-H1N1 influenza A viruses of 1977-1978.

A S Beare, A P Kendal, N J Cox, C Scholtissek
PMCID: PMC551014  PMID: 7399693

Abstract

A series of trials was conducted in which wild-type A/USSR/90/77 (H1N1) influenza A virus and a few of its antigenic variants were inoculated into volunteers. Infections readily occurred in people of all ages who had initial low antibody titers, but clinical effects were generally mild in comparison with those of the previously tested subtypes, H0N1, H1N1, H2N2, H3N2. There was, however, an inverse relationship between severity of symptoms and age of volunteers, although the incidence of virus excretion and of increase in anti-hemagglutinin was apparently not age related. Naturally occurring recombinant viruses with H3 hemagglutinin and one or more genes of A/USSR/098/77-like strains were likewise studied in volunteers. These clones also produced mild symptoms, providing evidence of an attenuating effect on H3N2 viruses by the substitution of some of its genes with the genes of an H1N1 virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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