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. 1980 Jul;29(1):8–12. doi: 10.1128/iai.29.1.8-12.1980

Role of complement in chemotaxis: study of a localized infection.

D M Wilson, D J Ormrod, T E Miller
PMCID: PMC551066  PMID: 6995344

Abstract

A model of Escherichia coli-induced pyelonephritis was used to study the effect of complement depletion in an organ-specific, nonimmunological inflammatory lesion in rats. In this model of a local infection, which can be considered to be nonspecific inflammatory stimulus, the depletion of complement by the administration of a purified cobra venom factor did not alter the course of the disease. There were minor differences when the results from complement-depleted and normocomplementemic animals were compared, but the composition of the inflammatory infiltrate was not greatly altered. Therefore, the presence of C3 and a functional complement system are relatively unimportant factors in determining the characteristics of the inflammatory response in a localized infection-induced lesion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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