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. 1980 Jul;29(1):36–41. doi: 10.1128/iai.29.1.36-41.1980

Immunosuppression and alterations of T-lymphocyte subpopulations after rubella vaccination.

P Arneborn, G Biberfeld, J Wasserman
PMCID: PMC551071  PMID: 6967455

Abstract

Lymphocyte stimulation tests and determinations of T-lymphocyte subpopulations were undertaken in 11 subjects before and after rubella vaccination and in 11 controls. The lymphocyte stimulation response to phytohemagglutinin was suppressed 7 to 10 days after vaccination. The proportion of T lymphocytes with receptors for the Fc part of immunoglobulin G increased after vaccination, whereas there was no significant change in the proportion of T lymphocytes with immunoglobulin M-Fc receptors.

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Selected References

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  1. Broder S., Waldmann T. A. The suppressor-cell network in cancer (second of two parts). N Engl J Med. 1978 Dec 14;299(24):1335–1341. doi: 10.1056/NEJM197812142992404. [DOI] [PubMed] [Google Scholar]
  2. Buimovici-Klein E., Cooper L. Z. Immunosuppression and isolation of rubella virus from human lymphocytes after vaccination with two rubella vaccines. Infect Immun. 1979 Jul;25(1):352–356. doi: 10.1128/iai.25.1.352-356.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Buimovici-Klein E., Vesikari T., Santangelo C. F., Cooper L. Z. Study of the lymphocyte in vitro response to rubella antigen and phytohemagglutinin by a whole blood method. Arch Virol. 1976;52(4):323–331. doi: 10.1007/BF01315621. [DOI] [PubMed] [Google Scholar]
  4. Bøyum A. Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol. 1976 Jun;Suppl 5:9–15. [PubMed] [Google Scholar]
  5. Ferrarini M., Moretta L., Abrile R., Durante M. L. Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells. Eur J Immunol. 1975 Jan;5(1):70–72. doi: 10.1002/eji.1830050115. [DOI] [PubMed] [Google Scholar]
  6. Finkel A., Dent P. B. Abnormalities in lymphocyte proliferation in classical and atypical measles infection. Cell Immunol. 1973 Jan;6(1):41–48. doi: 10.1016/0008-8749(73)90004-x. [DOI] [PubMed] [Google Scholar]
  7. Ganguly R., Cusumano C. L., Waldman R. H. Suppression of cell-mediated immunity after infection with attenuated rubella virus. Infect Immun. 1976 Feb;13(2):464–469. doi: 10.1128/iai.13.2.464-469.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Haider S., Coutinho M. de L., Emond R. T., Sutton R. N. Tuberculin anergy and infectious mononucleosis. Lancet. 1973 Jul 14;2(7820):74–74. doi: 10.1016/s0140-6736(73)93265-0. [DOI] [PubMed] [Google Scholar]
  9. Heijnen C. J., UytdeHaag F., Gmelig-Meyling F. H., Ballieux R. E. Localization of human antigen-specific helper and suppressor function in distinct T-cell subpopulations. Cell Immunol. 1979 Mar 15;43(2):282–292. doi: 10.1016/0008-8749(79)90173-4. [DOI] [PubMed] [Google Scholar]
  10. Jondal M. SRBC rosette formation as a human T lymphocyte marker. Scand J Immunol. 1976 Jun;Suppl 5:69–76. doi: 10.1111/j.1365-3083.1976.tb03857.x. [DOI] [PubMed] [Google Scholar]
  11. Katz P., Goldstein R. A., Fauci A. S. Immunoregulation in infection caused by Mycobacterium tuberculosis: the presence of suppressor monocytes and the alteration of subpopulations of T lymphocytes. J Infect Dis. 1979 Jul;140(1):12–21. doi: 10.1093/infdis/140.1.12. [DOI] [PubMed] [Google Scholar]
  12. Kauffman C. A., Phair J. P., Linnemann C. C., Jr, Schiff G. M. Cell-mediated immunity in humans during viral infection. I. Effect of rubella on dermal hypersensitivity, phytohemagglutinin response, and T lymphocyte numbers. Infect Immun. 1974 Jul;10(1):212–215. doi: 10.1128/iai.10.1.212-215.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Maller R., Frydén A., Sörén L. Mitogen stimulation and distribution of T- and B-lymphocytes during natural rubella infection. Acta Pathol Microbiol Scand C. 1978 Jun;86C(3):93–98. doi: 10.1111/j.1699-0463.1978.tb02564.x. [DOI] [PubMed] [Google Scholar]
  14. Maller R., Sörén L. In vitro effects of rubella virus, strain RA 27/3, on human lymphocytes. I. Viral inhibition of mitogen stimulation in relation to Rubella Haemagglutination inhibition antibodies. Acta Pathol Microbiol Scand C. 1977 Feb;85(1):49–56. doi: 10.1111/j.1699-0463.1977.tb03610.x. [DOI] [PubMed] [Google Scholar]
  15. Mangi R. J., Niederman J. C., Kelleher J. E., Jr, Dwyer J. M., Evans A. S., Kantor F. S. Depression of cell-mediated immunity during acute infectious mononucleosis. N Engl J Med. 1974 Nov 28;291(22):1149–1153. doi: 10.1056/NEJM197411282912202. [DOI] [PubMed] [Google Scholar]
  16. McMorrow L. E., Vesikari T., Wolman S. R., Giles J. P., Cooper L. Z. Suppression of the response of lymphocytes to phytohemagglutinin in rubella. J Infect Dis. 1974 Nov;130(5):464–469. doi: 10.1093/infdis/130.5.464. [DOI] [PubMed] [Google Scholar]
  17. Midulla M., Businco L., Moschini L. Some effects of rubella vaccination of immunologic responsiveness. Acta Paediatr Scand. 1972 Sep;61(5):609–611. doi: 10.1111/j.1651-2227.1972.tb15954.x. [DOI] [PubMed] [Google Scholar]
  18. Moretta L., Ferrarini M., Durante M. L., Mingari M. C. Expression of a receptor for IgM by human T cells in vitro. Eur J Immunol. 1975 Aug;5(8):565–569. doi: 10.1002/eji.1830050812. [DOI] [PubMed] [Google Scholar]
  19. Moretta L., Webb S. R., Grossi C. E., Lydyard P. M., Cooper M. D. Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG. J Exp Med. 1977 Jul 1;146(1):184–200. doi: 10.1084/jem.146.1.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Oldstone M. B., Tishon A., Moretta L. Active thymus derived suppressor lymphocytes in human cord blood. Nature. 1977 Sep 22;269(5626):333–335. doi: 10.1038/269333a0. [DOI] [PubMed] [Google Scholar]
  21. Pichler W. J., Lum L., Broder S. Fc-receptors on human T lymphocytes. I. Transition of Tgamma to Tmu cells. J Immunol. 1978 Oct;121(4):1540–1548. [PubMed] [Google Scholar]
  22. Skaug K., Orstavik I., Ulstrup J. C. Application of the passive haemolysis test for the determination of rubella virus antibodies. Acta Pathol Microbiol Scand B. 1975 Aug;83(4):367–372. doi: 10.1111/j.1699-0463.1975.tb00114.x. [DOI] [PubMed] [Google Scholar]
  23. Vesikari T., Buimovici-Klein E. Lymphocyte responses to rubella antigen and phytohemagglutinin after administration of the RA 27/3 strain of live attenuated rubella vaccine. Infect Immun. 1975 Apr;11(4):748–753. doi: 10.1128/iai.11.4.748-753.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Waldmann T. A., Broder S. Suppressor cells in the regulation of the immune response. Prog Clin Immunol. 1977;3:155–199. [PubMed] [Google Scholar]

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