Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1980 Jul;29(1):114–118. doi: 10.1128/iai.29.1.114-118.1980

Elevated glycosyltransferase activities in infected or traumatized hosts: nonspecific response to inflammation.

P G Canonico, J S Little, M C Powanda, K A Bostian, W R Beisel
PMCID: PMC551082  PMID: 6156910

Abstract

Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver during inflammatory processes. Serum sialyltransferase became elevated in bacteria-infected or burned rats and sandfly fever-infected humans, but did not correlate with acute-phase serum protein changes. These data suggest that nonparenchymal liver cells, such as macrophages, may contribute substantially to elevated sialyltransferase activity in the circulation during infection and, as such, represent a general host response to infection and tissue trauma.

Full text

PDF
114

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer C. H., Reutter W. G., Erhart K. P., Köttgen E., Gerok W. Decrease of human serum fucosyltransferase as an indicator of successful tumor therapy. Science. 1978 Sep 29;201(4362):1232–1233. doi: 10.1126/science.694511. [DOI] [PubMed] [Google Scholar]
  2. Bauer C., Köttgen E., Reutter W. Elevated activities of alpha-2-and alpha-3-fucosyltransferases in human serum as a new indicator of malignancy. Biochem Biophys Res Commun. 1976 May 23;76(2):488–494. doi: 10.1016/0006-291x(77)90751-3. [DOI] [PubMed] [Google Scholar]
  3. Beaufay H., Amar-Costesec A., Feytmans E., Thinès-Sempoux D., Wibo M., Robbi M., Berthet J. Analytical study of microsomes and isolated subcellular membranes from rat liver. I. Biochemical methods. J Cell Biol. 1974 Apr;61(1):188–200. doi: 10.1083/jcb.61.1.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bernacki R. J., Kim U. Concomitant elevations in serum sialytransferase activity and sialic acid content in rats with metastasizing mammary tumors. Science. 1977 Feb 11;195(4278):577–580. doi: 10.1126/science.835014. [DOI] [PubMed] [Google Scholar]
  5. Bosmann H. B., Hall T. C. Enzyme activity in invasive tumors of human breast and colon. Proc Natl Acad Sci U S A. 1974 May;71(5):1833–1837. doi: 10.1073/pnas.71.5.1833. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bostian K. A., Blackburn B. S., Wannemacher R. W., Jr, McGann V. G., Beisel W. R., Dupont H. L. Sequential changes in the concentration of specific serum proteins during typhoid fever infection in man. J Lab Clin Med. 1976 Apr;87(4):577–585. [PubMed] [Google Scholar]
  7. Canonico P. G., Beaufay H., Nyssens-Jadin M. Analytical fractionation of mouse peritoneal macrophages: physical and biochemical properties of subcellular organelles from resident (unstimulated) and cultivated cells. J Reticuloendothel Soc. 1978 Aug;24(2):115–138. [PubMed] [Google Scholar]
  8. Fidler I. J., Gersten D. M., Hart I. R. The biology of cancer invasion and metastasis. Adv Cancer Res. 1978;28:149–250. doi: 10.1016/s0065-230x(08)60648-x. [DOI] [PubMed] [Google Scholar]
  9. Henderson M., Kessel D. Alterations in plasma sialyltransferase levels in patients with neoplastic disease. Cancer. 1977 Mar;39(3):1129–1134. doi: 10.1002/1097-0142(197703)39:3<1129::aid-cncr2820390318>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  10. Ip C., Dao T. Alterations in serum glycosyltransferases and 5'-nucleotidase in breast cancer patients. Cancer Res. 1978 Mar;38(3):723–728. [PubMed] [Google Scholar]
  11. Ip C. Effect of partial hepatectomy and hydrocortisone administration on liver and serum sialyltransferase activities. Biochim Biophys Acta. 1979 Feb 19;583(1):14–19. doi: 10.1016/0304-4165(79)90304-0. [DOI] [PubMed] [Google Scholar]
  12. Kessel D., Sykes E., Henderson M. Glycosyltransferase levels in tumors metastatic to liver and in uninvolved liver tissue. J Natl Cancer Inst. 1977 Jul;59(1):29–32. doi: 10.1093/jnci/59.1.29. [DOI] [PubMed] [Google Scholar]
  13. Kim Y. S., Perdomo J., Whitehead J. S., Curtis K. J. Glycosyltransferases in human blood. II. Study of serum galactosyltransferase and N-acetylgalactosaminyltransferase in patients with liver diseases. J Clin Invest. 1972 Aug;51(8):2033–2039. doi: 10.1172/JCI107009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  15. Little J. S. Synthesis, transport, and secretion of plasma proteins by the livers of control and Streptococcus pneumoniae-infected rats. Infect Immun. 1978 Nov;22(2):585–596. doi: 10.1128/iai.22.2.585-596.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mookerjea S., Michaels M. A., Hudgin R. L., Moscarello M. A., Chow A., Schachter H. The levels of nucleotide-sugar: glycoprotein sialyl- and N-acetylglucosaminyltransferases in normal and pathological human sera. Can J Biochem. 1972 Jul;50(7):738–740. doi: 10.1139/o72-102. [DOI] [PubMed] [Google Scholar]
  17. Pekarek R. S., Beisel W. R., Bartelloni P. J., Bostian K. A. Determination of serum zinc concentrations in normal adult subjects by atomic absorption spectrophotometry. Am J Clin Pathol. 1972 Apr;57(4):506–510. doi: 10.1093/ajcp/57.4.506. [DOI] [PubMed] [Google Scholar]
  18. Podolsky D. K., Weiser M. M. Galactosyltransferase activities in human sera: detection of a cancer-associated isoenzyme. Biochem Biophys Res Commun. 1975 Jul 22;65(2):545–551. doi: 10.1016/s0006-291x(75)80181-1. [DOI] [PubMed] [Google Scholar]
  19. Powanda M. C. Changes in body balances of nitrogen and other key nutrients: description and underlying mechanisms. Am J Clin Nutr. 1977 Aug;30(8):1254–1268. doi: 10.1093/ajcn/30.8.1254. [DOI] [PubMed] [Google Scholar]
  20. Powanda M. C., Cockerell G. L., Pekarek R. S. Amino acid and zinc movement in relation to protein synthesis early in inflammation. Am J Physiol. 1973 Aug;225(2):399–401. doi: 10.1152/ajplegacy.1973.225.2.399. [DOI] [PubMed] [Google Scholar]
  21. Powanda M. C., Wannemacher R. W., Jr, Cockerell G. L. Nitrogen metabolism and protein synthesis during pneumococcal sepsis in rats. Infect Immun. 1972 Sep;6(3):266–271. doi: 10.1128/iai.6.3.266-271.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Roseman S. The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. Chem Phys Lipids. 1970 Oct;5(1):270–297. doi: 10.1016/0009-3084(70)90024-1. [DOI] [PubMed] [Google Scholar]
  23. SHETLAR M. R., BRYAN R. S. Serum polysaccharide levels in experimental inflammation. Proc Soc Exp Biol Med. 1949 Nov;72(2):294–296. doi: 10.3181/00379727-72-17412. [DOI] [PubMed] [Google Scholar]
  24. Schwartz M. K. Enzyme patterns in cancer. Ann Clin Lab Sci. 1977 Mar-Apr;7(2):99–104. [PubMed] [Google Scholar]
  25. Shah S. N., Raghupathy E. Differential effects of EDTA, metal ions, and nucleotides on glycoprotein sialyltransferase activity of serum and liver. Proc Soc Exp Biol Med. 1977 Sep;155(4):516–518. doi: 10.3181/00379727-155-39841. [DOI] [PubMed] [Google Scholar]
  26. WILLIAMS C. A., Jr, ASOFSKY R., THORBECKE G. J. PLASMA PROTEIN FORMATION IN VITRO BY TISSUES FROM MICE INFECTED WITH STAPHYLOCOCCI. J Exp Med. 1963 Aug 1;118:315–326. doi: 10.1084/jem.118.2.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Wannemacher R. W., Jr, Dinterman R. E., Pekarek R. S., Bartelloni P. J., Beisel W. R. Urinary amino acid excretion during experimentally induced sandfly fever in man. Am J Clin Nutr. 1975 Feb;28(2):110–118. doi: 10.1093/ajcn/28.2.110. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES