Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1980 Jul;29(1):287–289. doi: 10.1128/iai.29.1.287-289.1980

Cotransformation of a serum resistance phenotype with genes for arginine biosynthesis in Neisseria gonorrhoeae.

S K Spratt, F Jones, T E Shockley, J H Jackson
PMCID: PMC551111  PMID: 6447113

Abstract

Two genes (arg-3 and arp-6) marked by arginine auxotrophy and a gene (sac-2) marked by resistance to serum killing were found to be linked by cotransformation. Evidence derived from the linkage of these markers to spc (spectinomycin resistance) suggests that sac-2 may be genetically distinct from a sac gene previously described.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carifo K., Catlin B. W. Neisseria gonorrhoeae auxotyping: differentiation of clinical isolates based on growth responses on chemically defined media. Appl Microbiol. 1973 Sep;26(3):223–230. doi: 10.1128/am.26.3.223-230.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Catlin B. W. Nutritional profiles of Neisseria gonorrhoeae, Neisseria meningitidis, and Neisseria lactamica in chemically defined media and the use of growth requirements for gonococcal typing. J Infect Dis. 1973 Aug;128(2):178–194. doi: 10.1093/infdis/128.2.178. [DOI] [PubMed] [Google Scholar]
  3. Eisenstein B. I., Lee T. J., Sparling P. F. Penicillin sensitivity and serum resistance are independent attributes of strains of Neisseria gonorrhoeae causing disseminated gonococcal infection. Infect Immun. 1977 Mar;15(3):834–841. doi: 10.1128/iai.15.3.834-841.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Knapp J. S., Holmes K. K. Disseminated gonococcal infections caused by Neisseria gonorrhoeae with unique nutritional requirements. J Infect Dis. 1975 Aug;132(2):204–208. doi: 10.1093/infdis/132.2.204. [DOI] [PubMed] [Google Scholar]
  6. La Scolea L. J., Jr, Young F. E. Development of a defined minimal medium for the growth of Neisseria gonorrhoeae. Appl Microbiol. 1974 Jul;28(1):70–76. doi: 10.1128/am.28.1.70-76.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mayer L. W., Schoolnik G. K., Falkow S. Genetic studies on Neisseria gonorrhoeae from disseminated gonococcal infections. Infect Immun. 1977 Oct;18(1):165–172. doi: 10.1128/iai.18.1.165-172.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Morello J. A., Lerner S. A., Bohnhoff M. Characteristics of atypical Neisseria gonorrhoeae from disseminated and localized infections. Infect Immun. 1976 May;13(5):1510–1516. doi: 10.1128/iai.13.5.1510-1516.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Sarubbi F. A., Jr, Blackman E., Sparling P. F. Genetic mapping of linked antibiotic resistance loci in Neisseria gonorrhoeae. J Bacteriol. 1974 Dec;120(3):1284–1292. doi: 10.1128/jb.120.3.1284-1292.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Schoolnik G. K., Buchanan T. M., Holmes K. K. Gonococci causing disseminated gonococcal infection are resistant to the bactericidal action of normal human sera. J Clin Invest. 1976 Nov;58(5):1163–1173. doi: 10.1172/JCI108569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wiesner P. J., Handsfield H. H., Holmes K. K. Low antibiotic resistance of gonococci causing disseminated infection. N Engl J Med. 1973 Jun 7;288(23):1221–1222. doi: 10.1056/NEJM197306072882308. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES