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. 1980 Aug;29(2):390–394. doi: 10.1128/iai.29.2.390-394.1980

Evidence that botulinum C2 toxin has two dissimilar components.

M Iwasaki, I Ohishi, G Sakaguchi
PMCID: PMC551130  PMID: 7011974

Abstract

Botulinum C2 toxin produced by most toxigenic and nontoxigenic strains of Clostridium botulinum types C and D contains two distinct protein components, and these were separated by ion-exchange chromatography and gel filtration. Neither of these components manifested the original toxicity, but the original toxicity was restored when the two components were mixed together and trypsinized. This indicates that C2 toxin consists of two dissimilar protein components and that the cooperation of the two is required to elicit toxicity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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