Abstract
Heterotypic immunity to influenza virus in ferrets operated against heterotypic influenza viruses but not heterologous viruses. Contrary to prior reports, the protection conferred lasted for at least 18 months. This type of immunity limited virus shedding but did not prevent infection. These results suggest that this phenomenon could play a role in determining the severity of infections caused by type A influenza viruses in humans.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allan W. H., Madeley C. R., Kendal A. P. Studies with avian influenza A viruses: cross protection experiments in chickens. J Gen Virol. 1971 Aug;12(2):79–84. doi: 10.1099/0022-1317-12-2-79. [DOI] [PubMed] [Google Scholar]
- Barber W. H., Small P. A., Jr Dissemination of influenza virus between anatomically isolated sites in ferrets. Infect Immun. 1974 Mar;9(3):530–533. doi: 10.1128/iai.9.3.530-533.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McLaren C., Potter C. W. Immunity to influenza in ferrets. VII. Effect of previous infection with heterotypic and heterologous influenza viruses on the response of ferrets to inactivated influenza virus vaccines. J Hyg (Lond) 1974 Feb;72(1):91–100. doi: 10.1017/s0022172400023251. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHULMAN J. L., KILBOURNE E. D. INDUCTION OF PARTIAL SPECIFIC HETEROTYPIC IMMUNITY IN MICE BY A SINGLE INFECTION WITH INFLUENZA A VIRUS. J Bacteriol. 1965 Jan;89:170–174. doi: 10.1128/jb.89.1.170-174.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
- Small P. A., Jr, Waldman R. H., Bruno J. C., Gifford G. E. Influenza infection in ferrets: role of serum antibody in protection and recovery. Infect Immun. 1976 Feb;13(2):417–424. doi: 10.1128/iai.13.2.417-424.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yetter R. A., Lehrer S., Ramphal R., Small P. A., Jr Outcome of influenza infection: effect of site of initial infection and heterotypic immunity. Infect Immun. 1980 Aug;29(2):654–662. doi: 10.1128/iai.29.2.654-662.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]