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. 1990 Dec;87(23):9148–9152. doi: 10.1073/pnas.87.23.9148

cDNA clone encoding Drosophila transcription factor TFIID.

M L Muhich 1, C T Iida 1, M Horikoshi 1, R G Roeder 1, C S Parker 1
PMCID: PMC55121  PMID: 2123550

Abstract

Proper initiation of transcription by RNA polymerase II requires the TATA-consensus-binding transcription factor TFIID. A cDNA clone encoding the Drosophila TFIID protein has been isolated and characterized. The deduced amino acid sequence reveals an open reading frame of 353 residues. The carboxyl-terminal 180 amino acids are approximately 80% identical to yeast TFIID and 88% identical to human TFIID. The amino-terminal portions of the yeast and Drosophila TFIID proteins lack appreciable homology, whereas the Drosophila and human amino termini appear qualitatively similar. In addition, the amino-terminal region of the Drosophila TFIID contains several sequence motifs that are found in other Drosophila proteins which appear to regulate transcription.

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Selected References

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