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Infection and Immunity logoLink to Infection and Immunity
. 1980 Sep;29(3):886–891. doi: 10.1128/iai.29.3.886-891.1980

Iron-controlled infection with Neisseria meningitidis in mice.

B E Holbein
PMCID: PMC551213  PMID: 6159328

Abstract

An iron-controlled infection was obtained after the intraperitoneal infection of Neisseria meningitidis strain M1011 into normal mice. The infection progressed rapidly but then disappeared in concert with the disappearance of plasma transferrin iron. Parenteral iron dextran enhanced and prolonged the infection in mice at dosages above 15 mg of Fe per kg. Studies on the distribution of iron dextran within the physiological iron pools and the importance of timing with the iron dextran addition indicated that high serum iron, available early during infection, was necessary to promote infection. High levels of iron in the reticuloendothelial system did not stimulate infection. A working hypothesis to explain the roles of iron in infection was developed: N. meningitidis obtains iron for growth from the transferrin pool, and iron dextran maintains transferrin iron levels during infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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