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. 1980 Sep;29(3):940–944. doi: 10.1128/iai.29.3.940-944.1980

Virulence of tissue culture-propagated canine distemper virus.

A E Metzler, R J Higgins, S Krakowka, A Koestner
PMCID: PMC551221  PMID: 7429639

Abstract

Virulence of canine distemper virus (CDV) adapted to in vitro growth in Vero or bovine cells was determined by inoculation into CDV-susceptible neonatal gnotobiotic dogs. When compared with dogs given virulent R252-CDV, Vero R252-CDV was attenuated at passage level 14. In contrast, dogs inoculated with bovine R252-CDV at the same passage level experienced rapid fatal neurological disease. Virulence was not linked to ability to infect or replicate in canine pulmonary macrophage cultures. Retention of virulence by bovine R252-CDV is unique and worthy of further study.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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