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. 1980 Oct;30(1):58–61. doi: 10.1128/iai.30.1.58-61.1980

Activation of the alternative complement pathway by Naegleria fowleri.

T W Holbrook, R J Boackle, B W Parker, J Vesely
PMCID: PMC551276  PMID: 7439979

Abstract

Naegleria fowleri amoebae were lysed by adult fresh human serum, and their multiplication was inhibited in culture medium supplemented with 10% fresh human serum. Heat inactivation (56 degrees C, 30 min) of serum abrogated these lytic and inhibitory effects. Absorption of human serum with amoebae failed to reduce immunoglobulin levels, and no specific antibody was detected in untreated or treated sera by counterimmunoelectrophoresis. Conversion of C3 and C3i occurred after incubation of n. fowleri with serum which had been treated with ethylene glycol-bis(beta-aminoethyl ether)-N,N-tetraacetic acid, indicating activation of complement via the alternative pathway.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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