Abstract
Antibodies to human cytomegalovirus (CMV)-specific antigens were determined in sera serially collected from 10 infants with primary CMV infection. Antibodies to pre-early nuclear antigens (PENA), which are detectable in human embryonic lung cells within 3 h of CMV infection by anticomplement immunofluorescence staining, developed in all the patients. However, in contrast to the early response of anti-early antigens (EA), anti-late antigens (LA), and immunoglobulin M antimembrane antigens (MA), seroconversion or the maximum antibody response to PENA was usually observed 1 or more months later. Immunoglobulin M antibody to MA became undetectable soon after recovery from illness, followed by a decrease in anti-EA, anti-PENA, and then anti-LA titers. Results indicated analogy of the clinical significance of anti-PENA in CMV infection to that of anti-Epstein-Barr nuclear antigen in infectious mononucleosis and support the idea that parallel determinations of anti-PENA and IgM anti-MA antibodies can be useful for identifying the acute or chronic phase of primary CMV infection.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Geder L. Evidence for early nuclear antigens in cytomegalovirus-infected cells. J Gen Virol. 1976 Aug;32(2):315–319. doi: 10.1099/0022-1317-32-2-315. [DOI] [PubMed] [Google Scholar]
- HALLAUER C., KRONAUER G. EXTRACTION OF CELL-ASSOCIATED VIRUS WITHOUT DAMAGE OF THE CULTURE. (BRIEF REPORT). Arch Gesamte Virusforsch. 1965;15:433–440. doi: 10.1007/BF01241771. [DOI] [PubMed] [Google Scholar]
- Henie G., Henle W., Horwitz C. A. Antibodies to Epstein-Barr virus-associated nuclear antigen in infectious mononucleosis. J Infect Dis. 1974 Sep;130(3):231–239. doi: 10.1093/infdis/130.3.231. [DOI] [PubMed] [Google Scholar]
- Hirai K., Maeda F., Watanabe Y. Expression of early virus functions in human cytomegalovirus infected HEL cells: effect of ultraviolet light-irradiation of the virus. J Gen Virol. 1978 Jan;38(1):121–133. doi: 10.1099/0022-1317-38-1-121. [DOI] [PubMed] [Google Scholar]
- Ohtsuka M., Tanaka S., Saitho H., Hashimoto K. Seroconversion to human-cytomegalovirus-specific pre-early nuclear antigens in renal transplant recipients. Microbiol Immunol. 1979;23(5):349–355. doi: 10.1111/j.1348-0421.1979.tb00472.x. [DOI] [PubMed] [Google Scholar]
- Reedman B. M., Klein G. Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines. Int J Cancer. 1973 May;11(3):499–520. doi: 10.1002/ijc.2910110302. [DOI] [PubMed] [Google Scholar]
- SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
- Stagno S., Pass R. F., Reynolds D. W., Moore M. A., Nahmias A. J., Alford C. A. Comparative study of diagnostic procedures for congenital cytomegalovirus infection. Pediatrics. 1980 Feb;65(2):251–257. [PubMed] [Google Scholar]
- Tanaka S., Otsuka M., Ihara S., Maeda F., Watanabe Y. Induction of pre-early nuclear antigen(s) in HEL cells infected with human cytomegalovirus. Microbiol Immunol. 1979;23(4):263–271. doi: 10.1111/j.1348-0421.1979.tb00462.x. [DOI] [PubMed] [Google Scholar]
- The T. H., Klein G., Langenhuysen M. M. Antibody reactions to virus-specific early antigens (EA) in patients with cytomegalovirus (CMV) infection. Clin Exp Immunol. 1974 Jan;16(1):1-7,9-12. [PMC free article] [PubMed] [Google Scholar]
- The T. H., Langenhuysen M. M. Antibodies against membrane antigens of cytomegalovirus infected cells in sera of patients with a cytomegalovirus infection. Clin Exp Immunol. 1972 Aug;11(4):475–482. [PMC free article] [PubMed] [Google Scholar]
- Westmoreland D., St Jeor S., Rapp F. The development by cytomegalovirus-infected cells of binding affinity for normal human immunoglobulin. J Immunol. 1976 Jun;116(6):1566–1570. [PubMed] [Google Scholar]