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. 1980 Oct;30(1):219–223. doi: 10.1128/iai.30.1.219-223.1980

Epidemic typhus infection in cynomolgus monkeys (Macaca fascicularis).

J C Gonder, R H Kenyon, C E Pedersen Jr
PMCID: PMC551298  PMID: 7439974

Abstract

A nonhuman primate model of clinical Rickettsia prowazekii infections was developed in cynomolgus monkeys (Macaca fascicularis). Monkeys infected intravenously with 10(7) plaque-forming units developed clinical signs of illness and pathological changes characteristic of epidemic typhus infection in humans. Increases in total leukocyte counts, serum alkaline phosphatase, blood urea nitrogen, and serum glutamic pyruvate transaminase values were observed. Microscopic examination revealed typical typhus nodules in the brains of two monkeys that died. These data indicated that the cynomolgus monkey is a suitable model for study of the pathogenesis of epidemic typhus infection and may prove valuable in the evaluation of candidate R. prowazekii vaccines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barker L. F., Palmer A. E., Kirschstein R. L., Hopps H. E., Patt J. K. Experimental infection with Rickettsia prowazeki in rhesus and vervet monkeys. J Infect Dis. 1967 Oct;117(4):285–291. doi: 10.1093/infdis/117.4.285. [DOI] [PubMed] [Google Scholar]
  2. NEVA F. A., SNYDER J. C. Studies on the toxicity of typhus rickettsiae. I. Susceptibility of the white rat, with a note on pathologic changes. J Infect Dis. 1952 Jul-Aug;91(1):72–78. doi: 10.1093/infdis/91.1.72. [DOI] [PubMed] [Google Scholar]
  3. Ormsbee R., Peacock M., Gerloff R., Tallent G., Wike D. Limits of rickettsial infectivity. Infect Immun. 1978 Jan;19(1):239–245. doi: 10.1128/iai.19.1.239-245.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Philip C. B., Hughes L. E., Lackman D. B., Bell E. J. Susceptibility of certain domestic animals to experimental infection with Rickettsia prowazekii. Am J Trop Med Hyg. 1967 Nov;16(6):758–761. [PubMed] [Google Scholar]

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