Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1980 Nov;30(2):321–324. doi: 10.1128/iai.30.2.321-324.1980

Protection against keratoconjunctivitis shigellosa induced by immunization with outer membrane proteins of Shigella spp.

G Adamus, M Mulczyk, D Witkowska, E Romanowska
PMCID: PMC551312  PMID: 7002794

Abstract

Active immunization of guinea pigs and rabbits with outer membrane proteins (OMP) isolated from Shigella flexneri 3a and Shigella sonnei phase I protected the animals against keratoconjunctivitis shigellosa induced with the homologous or heterologous strain. Protection was also achieved in rabbits after passive immunization with anti-OMP immune serum. Active immunization with lipopolysaccharide of S. flexneri 3a did not protect rabbits against keratoconjunctivitis shigellosa.

Full text

PDF
321

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Formal S. B., Labrec E. H., Palmer A., Falkow S. Protection of Monkeys Against Experimental Shigellosis with Attenuated Vaccines. J Bacteriol. 1965 Jul;90(1):63–68. doi: 10.1128/jb.90.1.63-68.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Kowalewska D., Mulczyk M. Immunity to keratoconjunctivitis shigellosa in rabbits after oral immunization with Shigella sonnei free endotoxin. Acta Microbiol Acad Sci Hung. 1974;21(1-2):99–102. [PubMed] [Google Scholar]
  3. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  4. MANOLOV D. G. A study of some questions of pathogenicity and immunity in dysentery using experimental models of Shigella keratoconjunctivitis in guinea pigs. J Hyg Epidemiol Microbiol Immunol. 1957;1(3):322–328. [PubMed] [Google Scholar]
  5. Mel D. M., Arsić B. L., Nikolić B. D., Radovanić M. L. Studies on vaccination against bacillary dysentery. 4. Oral immunization with live monotypic and combined vaccines. Bull World Health Organ. 1968;39(3):375–380. [PMC free article] [PubMed] [Google Scholar]
  6. Mel D., Gangarosa E. J., Radovanovic M. L., Arsic B. L., Litvinjenko S. Studies on vaccination against bacillary dysentery. 6. Protection of children by oral immunization with streptomycin-dependent Shigella strains. Bull World Health Organ. 1971;45(4):457–464. [PMC free article] [PubMed] [Google Scholar]
  7. Romanowska E., Pelczarska A., Wnuk W., Mulczyk M., Godzińska H., Slopek S. Isolation, purification and physico-chemical characteristic of Shigella sonnei phase I free endotoxin. Eur J Biochem. 1970 Feb;12(3):435–441. doi: 10.1111/j.1432-1033.1970.tb00870.x. [DOI] [PubMed] [Google Scholar]
  8. Romanowska E. Sepharose gel filtration method of purification of lipopolysaccharides. Anal Biochem. 1970 Feb;33(2):383–389. doi: 10.1016/0003-2697(70)90309-x. [DOI] [PubMed] [Google Scholar]
  9. SERENY B. A new method for the measurement of protective potency of dysentery vaccines. Acta Microbiol Acad Sci Hung. 1962;9:55–60. [PubMed] [Google Scholar]
  10. SERENY B. Acquired natural immunity following recovery from keratoconjunctivitis shigellosa. J Hyg Epidemiol Microbiol Immunol. 1959;3:292–305. [PubMed] [Google Scholar]
  11. SERENY B. Experimental keratoconjunctivitis shigellosa. Acta Microbiol Acad Sci Hung. 1957;4(4):367–376. [PubMed] [Google Scholar]
  12. Schnaitman C. A. Outer membrane proteins of Escherichia coli. 3. Evidence that the major protein of Escherichia coli O111 outer membrane consists of four distinct polypeptide species. J Bacteriol. 1974 May;118(2):442–453. doi: 10.1128/jb.118.2.442-453.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. TRUSZCZYNSKI M., BAKER E. E. Inhibition with simple sugars of hemagglutination of red cells modified with Salmonella antigens. J Immunol. 1962 Jul;89:154–159. [PubMed] [Google Scholar]
  14. Witkowska D., Mulczyk M. Studies on virulence of Shigella flexneri. Arch Immunol Ther Exp (Warsz) 1978;26(1-6):603–610. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES