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. 1980 Nov;30(2):439–444. doi: 10.1128/iai.30.2.439-444.1980

Role of the central nervous system in acute-phase responses to leukocytic pyrogen.

J B Turchik, D L Bornstein
PMCID: PMC551332  PMID: 7439989

Abstract

Intracerebroventricular injection of rabbit leukocytic pyrogen (LP) into conscious, healthy cannulated rabbits produced markedly enhanced febrile and acute-phase responses as compared with equivalent-dose, single bolus intravenous injection. The increased effectiveness in inducing granulocytosis and hypoferremia on intracerebroventricular injection was matched by changing the method of administration of intravenous LP from a single initial bolus to multiple fractional doses over a 2-h period. This suggested that augmentation for these parameters may have reflected only a "reservoir" function of the cerebral ventricles which prevented rapid clearance of LP from the blood. The ability of LP to induce hepatic synthesis of haptoglobin and C-reactive protein was so markedly enhanced by intracerebroventricular injection, however, that a role of the central nervous system in mediating or in modifying in an important way a non-neural mechanism for this mediation must be postulated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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