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. 1980 Nov;30(2):554–561. doi: 10.1128/iai.30.2.554-561.1980

Effect of piliation on Klebsiella pneumoniae infection in rat bladders.

R C Fader, C P Davis
PMCID: PMC551347  PMID: 6108291

Abstract

The possible role of pili in the pathogenesis of urinary tract infection caused by Klebsiella pneumoniae was investigated in a rat model of cystitis by utilizing piliated- and nonpiliated-phase organisms derived from a single parent strain. Bladder surfaces were examined for evidence of infection by scanning electron microscopy. In animals infected with piliated-phase organisms, foci of infection were evident in the majority of bladders examined. Rat bladders associated with nonpiliated-phase bacteria showed little evidence of infection. The ability of methyl-D-mannoside, a known inhibitor of pilus-mediated adherence to mammalian cells, to protect the bladder surface from colonization was also tested. The results showed a significant decrease in the ability of piliated-phase K. pneumoniae to establish infection in bladders. These observations suggest that pili may play an integral role in the ability of K. pneumoniae to cause urinary tract infections by mediating the attachment of the bacteria to the uroepithelial surface.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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