Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1980 Dec;30(3):791–796. doi: 10.1128/iai.30.3.791-796.1980

Effect of Corynebacterium granulosum immunopotentiation on the pathogenesis of herpes simplex virus type 2 in BALB/c mice.

D A Gabrielson, J J Kelleher, J Varani
PMCID: PMC551385  PMID: 6262241

Abstract

Treatment of 4- to 6-week-old, 18- to 22-g male BALB/c mice with 0.6 mg of Corynebacterium granulosum resulted in a significant decrease in mortality due to challenge with herpes simplex virus type 2 (HSV-2). Optimal protection occurred when C. granulosum was injected 1 week before HSV-2 infection. C. granulosum-induced resistance to HSV-2 lasted up to 4.5 weeks. Studies involving immune spleen cell transfer and treatment with antilymphocyte serum demonstrated the importance of cell-mediated immunity in HSV-2 infection. However, C. granulosum protection was not transferable with spleen cells from C. granulosum-treated animals nor was C. granulosum treatment capable of completely overcoming the increased mortality which resulted from antilymphocyte serum treatment of HSV-2 infected mice. Under our experimental conditions, silica did not affect the mortality in BALB/c mice due to HSV-2 but significantly reduced the protective effects induced by C. granulosum. Attempts to transfer protection of HSV-2 challenge in suckling mice by using either glass-adherent or mixed peritoneal cells from either HSV-2-immunized or C. granulosum-treated animals were unsuccessful.

Full text

PDF
791

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adlam C., Broughton E. S., Scott M. T. Enhanced resistance of mice to infection with bacteria following pre-treatment with Corynebacterium parvum. Nat New Biol. 1972 Feb 16;235(59):219–220. doi: 10.1038/newbio235219a0. [DOI] [PubMed] [Google Scholar]
  2. Adlam C., Scott M. T. Lympho-reticular stimulatory properties of Corynebacterium parvum and related bacteria. J Med Microbiol. 1973 Aug;6(3):261–274. doi: 10.1099/00222615-6-3-261. [DOI] [PubMed] [Google Scholar]
  3. Aurelian L., Strnad B. C. Herpesvirus type 2-related antigens and their relevance to humoral and cell-mediated immunity in patients with cervical cancer. Cancer Res. 1976 Feb;36(2 Pt 2):810–820. [PubMed] [Google Scholar]
  4. Bomford R., Christie G. H. Mechanisms of macrophage activation by corynebacterium parvum. II. In vivo experiments. Cell Immunol. 1975 May;17(1):150–155. doi: 10.1016/s0008-8749(75)80015-3. [DOI] [PubMed] [Google Scholar]
  5. Catalano L. W., Jr, London W. T., Rice J. M., Sever J. L. Prophylactic and therapeutic use of poly(I)-poly(C) (poly-D-lysine) against herpesvirus encephalitis in mice. Proc Soc Exp Biol Med. 1972 May;140(1):66–71. doi: 10.3181/00379727-140-36396. [DOI] [PubMed] [Google Scholar]
  6. Dimitrov N. V., Andre S., Eliopoulos G., Halpern B. Effect of corynebacterium parvum on bone marrow cell cultures (38557). Proc Soc Exp Biol Med. 1975 Feb;148(2):440–442. doi: 10.3181/00379727-148-38557. [DOI] [PubMed] [Google Scholar]
  7. Ghaffar A., Cullen R. T., Dunbar N., Woodruff M. F. Anti-tumour effect in vitro of lymphocytes and macrophages from mice treated with Corynebacterium parvum. Br J Cancer. 1974 Mar;29(3):199–205. doi: 10.1038/bjc.1974.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HALPERN B. N., PREVOT A. R., BIOZZI G., STIFFEL C., MOUTON D., MORARD J. C., BOUTHILLIER Y., DECREUSEFOND C. STIMULATION DE L'ACTIVIT'E PHAGOCYTAIRE DU SYST'EME R'ETICULOENDOTH'ELIAL PROVOQU'EE PAR CORYNEBACTERIUM PARVUM. J Reticuloendothel Soc. 1964 Jan;1:77–96. [PubMed] [Google Scholar]
  9. Halpern B. N., Biozzi G., Stiffel C., Mouton D. Inhibition of tumour growth by administration of killed corynebacterium parvum. Nature. 1966 Nov 19;212(5064):853–854. doi: 10.1038/212853a0. [DOI] [PubMed] [Google Scholar]
  10. Hirsch M. S., Zisman B., Allison A. C. Macrophages and age-dependent resistance to Herpes simplex virus in mice. J Immunol. 1970 May;104(5):1160–1165. [PubMed] [Google Scholar]
  11. Hirt H. M., Becker H., Kirchner H. Induction of interferon production in mouse spleen cell cultures by corynebacterium parvum. Cell Immunol. 1978 Jun;38(1):168–175. doi: 10.1016/0008-8749(78)90042-4. [DOI] [PubMed] [Google Scholar]
  12. Kelleher J. J., Varani J., Nelson W. W. Establishment of a nonproductive herpes simplex virus infection in rabbit kidney cells. Infect Immun. 1975 Jul;12(1):128–133. doi: 10.1128/iai.12.1.128-133.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kelleher J. J., Varani J. Photoinactivation of latent herpes simplex virus in rabbit kidney cells. Antimicrob Agents Chemother. 1976 Aug;10(2):229–233. doi: 10.1128/aac.10.2.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kirchner H., Hirt H. M., Munk K. Protection against herpes simplex virus infection in mice by Corynebacterium parvum. Infect Immun. 1977 Apr;16(1):9–11. doi: 10.1128/iai.16.1.9-11.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kirchner H., Scott M. T., Hirt H. M., Munk K. Protection of mice against viral infection by Corynebacterium parvum and Bordetella pertussis. J Gen Virol. 1978 Oct;41(1):97–104. doi: 10.1099/0022-1317-41-1-97. [DOI] [PubMed] [Google Scholar]
  16. LINZENMEIER G. Etude sérologique des corynébactéries anaérobies par la methode des agglutinines. Ann Inst Pasteur (Paris) 1954 Nov;87(5):572–579. [PubMed] [Google Scholar]
  17. Milas L., Scott M. T. Antitumor activity of Corynebacterium parvum. Adv Cancer Res. 1978;26:257–306. doi: 10.1016/s0065-230x(08)60090-1. [DOI] [PubMed] [Google Scholar]
  18. Nussenzweig R. S. Increased nonspecific resstance to malaria produced by administration of killed Corynebacterium parvum. Exp Parasitol. 1967 Oct;21(2):224–231. doi: 10.1016/0014-4894(67)90084-7. [DOI] [PubMed] [Google Scholar]
  19. PREVOT A. R., DEZEST G., LEVADITI J. Réticulose expérimentale mortelle du lapin à Corynébactéries anaérobies. C R Hebd Seances Acad Sci. 1954 May 10;238(19):1937–1938. [PubMed] [Google Scholar]
  20. Rager-Zisman B., Allison A. C. Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection. J Immunol. 1976 Jan;116(1):35–40. [PubMed] [Google Scholar]
  21. Scott M. T. Corynebacterium parvum as an immunotherapeutic anticancer agent. Semin Oncol. 1974 Dec;1(4):367–378. [PubMed] [Google Scholar]
  22. Scott M. T. In vivo cortisone sensitivity of nonspecific antitumor activity of Corynebacterium parvum-activated mouse peritoneal macrophages. J Natl Cancer Inst. 1975 Mar;54(3):789–792. doi: 10.1093/jnci/54.3.789. [DOI] [PubMed] [Google Scholar]
  23. Stevens J. G., Cook M. L. Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction. J Exp Med. 1971 Jan 1;133(1):19–38. doi: 10.1084/jem.133.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Tuttle R. L., North R. J. Mchanisms of antitumor action of Corynebacterium parvum: nonspecific tumor cell destruction at site of immunologically mediated sensitivity reaction to C. parvum. J Natl Cancer Inst. 1975 Dec;55(6):1403–1411. doi: 10.1093/jnci/55.6.1403. [DOI] [PubMed] [Google Scholar]
  25. Woodruff M. F., Boak J. L. Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts. Br J Cancer. 1966 Jun;20(2):345–355. doi: 10.1038/bjc.1966.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Woodruff M. F., McBride W. H., Dunbar N. Tumour growth, phagocytic activity and antibody response in Corynebacterium parvum-treated mice. Clin Exp Immunol. 1974 Jul;17(3):509–518. [PMC free article] [PubMed] [Google Scholar]
  27. Yamaura K., Kato H., Hanazawa S., Yamaguchi Y. Induction of interferon in mice injected with heat-killed Corynebacterium anaerobium. Jpn J Exp Med. 1978 Feb;48(1):69–70. [PubMed] [Google Scholar]
  28. Zisman B., Hirsch M. S., Allison A. C. Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice. J Immunol. 1970 May;104(5):1155–1159. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES