Table 5.
Dementia (n = 205) | Controls (n = 107) | |||||
---|---|---|---|---|---|---|
Adiponectin | Leptin | Resistin | Adiponectin | Leptin | Resistin | |
Age | ||||||
R | 0.132 | 0.034 | 0.300 | 0.025 | −0.064 | 0.294 |
p value | 0.059 | 0.633 | 0.00001 | 0.797 | 0.516 | 0.002 |
MMSE | ||||||
R | −0.119 | 0.063 | 0.007 | – | – | – |
p value | 0.089 | 0.372 | 0.926 | |||
BMI | ||||||
R | −0.519 | 0.644 | 0.014 | −0.324 | 0.529 | 0.034 |
p value | <0.000001 | <0.0000001 | 0.837 | 0.0007 | <0.0000001 | 0.729 |
Glucose 0 h | ||||||
R | −0.234 | 0.184 | −0.003 | −0.293 | 0.264 | 0.075 |
p value | 0.0007 | 0.008 | 0.971 | 0.002 | 0.006 | 0.442 |
Insulin | ||||||
R | −0.360 | 0.402 | −0.057 | −0.409 | 0.228 | 0.084 |
p value | <0.000001 | <0.0000001 | 0.415 | 0.00001 | 0.018 | 0.390 |
HOMA-IR | ||||||
R | −0.402 | 0.415 | −0.046 | −0.457 | 0.278 | 0.099 |
p value | <0.000001 | <0.000001 | 0.514 | 0.000001 | 0.004 | 0.309 |
IL-6 | ||||||
R | −0.187 | 0.153 | 0.340 | −0.224 | 0.023 | 0.260 |
p value | 0.007 | 0.029 | 0.0000001 | 0.020 | 0.812 | 0.007 |
hsCRP | ||||||
R | −0.170 | 0.314 | 0.234 | −0.096 | 0.205 | 0.048 |
p value | 0.015 | 0.00004 | 0.0007 | 0.324 | 0.034 | 0.626 |
25-OH Vitamin D | ||||||
R | 0.082 | −0.085 | −0.132 | −0.027 | −0.099 | 0.018 |
p value | 0.244 | 0.227 | 0.060 | 0.780 | 0.309 | 0.853 |
PON1 | ||||||
R | −0.024 | 0.042 | −0.236 | 0.099 | 0.107 | −0.166 |
p value | 0.727 | 0.545 | 0.0006 | 0.310 | 0.272 | 0.088 |
HDL-C | ||||||
R | 0.499 | −0.263 | −0.301 | 0.311 | 0.025 | 0.094 |
p value | <0.0000001 | 0.0001 | 0.00001 | 0.001 | 0.801 | 0.334 |
Chitotriosidase | ||||||
R | −0.035 | 0.077 | 0.165 | 0.125 | 0.125 | −0.093 |
p value | 0.617 | 0.274 | 0.018 | 0.201 | 0.199 | 0.341 |
Spearman’s correlation coefficients (R) of adiponectin, leptin and resistin level with selected metabolic parameters and inflammation indices in dementia and controls
BMI body mass index, CRP C-reactive protein, HDL-C high density lipoprotein cholesterol, HOMA-IR homeostatic model assessment index, IL-6 interleukin 6, MMSE mini mental state examination, PON1 paraoxonase 1