Fig. 1.

Association of MALDI-MSI and top-down microproteomics. (a) MALDI-MSI of lipids and optical image, (b) histological annotation and segmentation analysis using the Bisecting k-Means and Correlation Distance approach (left). (c) Venn diagram of the top-down gene reference products identified in the ovarian cancer tissue by the LMJ approach, the PAM approach and total, (d) Precursor and HCD fragmentation scan of Keratin 2 cytoskeletal 8 fragment 425–483 and Macrophage migration inhibitory factor (MIF).