Table 3.
Median (IQR) of total aluminum concentrations [nmol/g dry weight] in breast tissue samples of cases and controls stratified by underarm cosmetic product (UCP) use.
| Cases | n | Controls | n |
p-value sampling location |
p-value UCP use |
p-value cases vs controls |
|
|---|---|---|---|---|---|---|---|
| Median (IQR) of Al3 + concentrationa | 5·77 (2·29–12·90) | 100 | 3·77 (2·47–5·78) | 52 | 0·0014 | ||
| UCP use in women when they were under the age of 30b | |||||||
| Never | 3·58 (1·72–9·25) | 28 | 2·74 (1·90–4·21) | 11 | 0·100 | 0·0344 | 0·0269 |
| Several times per week | 7·77 (4·74–11·40) | 9 | 3·07 (2·75–4·52) | 4 | |||
| Daily | 6·07 (2·21–14·89) | 53 | 4·34 (2·67–6·42) | 34 | |||
| Several times per day | 11·29 (3·62–13·21) | 9 | 2·51 (1·86–4·86) | 3 | |||
| UCP use during last 5 years before BC diagnosis in cases/during last 5 years before interview in controlsb | |||||||
| Never | 3·58 (1·72–7·32) | 20 | 3·32 (1·90–4·21) | 10 | 0·251 | 0·0093 | 0·0376 |
| Several times per week | 7·74 (3·23–11·40) | 10 | 3·07 (2·55–5·86) | 6 | |||
| Daily | 6·07 (2·34–14·89) | 57 | 3·96 (2·54–5·99) | 31 | |||
| Several times per day | 12·10 (3·50–14·68) | 12 | 4·86 (2·51–10·23) | 5 | |||
a
Independent samples t-test with log10(x + 1) transformed data.
b
Three-way analysis of variance with log10(x + 1) transformed data. Repeated aluminum measurements at three different sampling locations (upper outer, mammilla and lower inner breast quadrant) were considered as within-subject factor in the ANOVA.