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. Author manuscript; available in PMC: 2017 Jul 18.
Published in final edited form as: Nature. 2016 Sep 7;538(7625):344–349. doi: 10.1038/nature19804

Figure 2. Structures of key compounds, SSAR study of BRD3444 and X-ray crystal structure of BRD7929.

Figure 2

a, Structures of four bicyclic azetidine compounds. b, SSAR of BRD3444 showing that stereoisomers at the C2 position are equipotent, which suggests that this position is not necessary for activity. c, X-ray crystal structure of BRD7929 showing 3D conformation (BRD7929 was crystallized as a salt with two equivalents of l-tartaric acid; only the structure of BRD7929 is shown for clarity).