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. 1990 Dec;87(23):9411–9415. doi: 10.1073/pnas.87.23.9411

Expression and chromosomal localization of a lymphocyte K+ channel gene.

S Grissmer 1, B Dethlefs 1, J J Wasmuth 1, A L Goldin 1, G A Gutman 1, M D Cahalan 1, K G Chandy 1
PMCID: PMC55175  PMID: 2251283

Abstract

We recently isolated a family of three closely related mouse K+ channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons. Here we have used patch-clamp recordings from Xenopus oocytes injected with mRNA to show that MK3 encodes a channel with biophysical and pharmacological properties indistinguishable from those of voltage-gated type n K+ channels in T cells. In addition, we used the polymerase chain reaction to demonstrate the presence of MK3 mRNA in T cells. These data suggest that MK3 may encode the T-cell voltage-gated type n K+ channel. We also show that MK3 and MK2 are localized on human chromosomes 13 and 12, respectively.

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Selected References

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