E6020 increased myelin phagocytosis by BMDMs. (a) Quantification of myelin-containing rat BMDMs treated with pHrodo Red tagged rat myelin and Media or E6020 (1 µg/mL) for 2, 4, or 24 hr in vitro. (b–d) High power representative images of Media (b, 2h) and E6020 (c, 2 hr; d, 24 hr) treatment showing Phalloidin+ BMDMs (green) containing myelin (red) with nuclear counterstain Hoechst (blue). *p < .05, ***p < .001 versus Media. Scale bar = 100 µm (b–d). Data are mean ±SEM. [Color figure can be viewed at wileyonlinelibrary.com]