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. 2017 Jan 25;42(8):1657–1669. doi: 10.1038/npp.2017.6

Figure 2.

Figure 2

Tet1 KO from NAc induces antidepressant- and anxiolytic-like effects. (a) Floxed Tet1 mice that received AAV-Cre in NAc exhibit increased sucrose preference (N=15 for each group. Two-tailed t-test, *P=0.023). (b) Cre mice also spent more time in the center zone in the open filed test (N=15 for each group. Two-tailed t-test, *P=0.024) and (c) spent more time in the open arms in the EPM (N=15 for each group. Two-tailed t-test, **P=0.008). (d) Cre mice exhibited a partial rescue of social avoidance after CSDS (N=13 for each group. Two-tailed t-test, **P=0.004). (e) Cre mice demonstrated a greater percentage (**P=0.001 by a chi-squared test) of resilience (69% resilient vs 31% susceptible) than control mice (46% resilient vs 54% susceptible) 1 month after CSDS.