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. 2017 Jul 21;18:343. doi: 10.1186/s13063-017-2031-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) figure showing important events in the trial and their respective time points. EASI - Eczema Area and Severity Index, POEM Patient Oriented Eczema Measure, EQ-5D-5 L – EuroQol Five Dimension, CHU-9D – The Child Health Utility. ¹The 24 month is a face-to-face visit from the research nurses blinded to treatment allocation. ²Hayfever status assessed at 60 month only. ³Washing practices only