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Angiotensin-(1–4) but not angiotensin-(5–7) promotes insulin secretion only in islets expressing neprilysin. Insulin secretion in response to 2.8 or 20 mmol/L glucose from islets after a 48-h culture in the absence or presence of 1 nmol/L angiotensin-(1–4) (A: C57BL/6.NEP+/+, n = 6; B: C57BL/6.NEP−/−, n = 8) or 1 nmol/L angiotensin-(5–7) (C: C57BL/6.NEP+/+, n = 7; D: C57BL/6.NEP−/−, n = 7). Data are the mean ± SEM. *P < 0.05 vs. vehicle.
