Figure 2.

Cardiac effects of liraglutide. Representative PV relationships of saline-treated (A) and liraglutide-treated (B) animals before dobutamine administration (solid lines) and at 10 μg/kg/min after dobutamine (dashed lines). Dobutamine administration resulted in a profound leftward shift in saline-treated animals that was attenuated in liraglutide-treated animals. C: The volume axis intercept (V₀) was significantly lower across the range of dobutamine infusions. D: Ees did not increase across a range of dobutamine administration in saline-treated animals but was significantly increased at the highest dobutamine dose in liraglutide-treated animals relative to saline-treated animals. Values for panels C and D are mean ± SE for saline (n = 5) and liraglutide (n = 7). *P < 0.05 vs. baseline value (same treatment). †P < 0.05 vs. dobutamine infusion rate-matched, saline controls.