Figure 4.

Liraglutide increases CO via a load-independent mechanism. Liraglutide treatment resulted in an increase in the slope of the relationship between CO and EDV (P = 0.002 by ANCOVA). As defined by the Frank-Starling law of the heart, a load-dependent increase in CO would result in a shift of values that would still fit the control line. A change in slope is indicative of a load-independent increase in CO. This analysis includes data points from all animals at all measurement points. Saline (n = 5) and liraglutide (n = 7).