Table 4. Individual characteristics of patients with MET exon 14 splice site mutations.
| Patient | cDNA MET position* | Chr7 startposition** | Chr7 endposition** | Age (Years) | Gender | Ethnicity | Smoking history | Histology | Othermutations |
|---|---|---|---|---|---|---|---|---|---|
| #1 | c3082g>a; | 116771987 | 116771987 | 75 | Male | Caucasian | Current | SC Spindle and giant cell carcinoma | EGFR G719A |
| #2 | exon 14 +2 t>g | 116771989 | 116771989 | 65 | Female | Caucasian | Current | SC Pleomorphic carcinoma (ADK and Spindle cell carcinoma) | - |
| #9 | exon 14 -55_-54insCT | 116771796 | 116771797 | 66 | Female | Arab | Current | SC Giant cell carcinoma | - |
| #10 | exon 14 -47c>t | 116771802 | 116771802 | 68 | Female | Caucasian | Ex-smoker | SC Giant cell carcinoma | KRAS G12C |
| #3 | c3082g>a; | 116771987 | 116771987 | 84 | Female | Never smoker | ADC | - | |
| #4 | c3082g>t; | 116771987 | 116771987 | 64 | Female | Ex-smoker | ADC | - | |
| #5 | exon 14 -39_2947del45pb | 116771810 | 116771854 | 79 | Male | African | Never smoker | ADC | - |
| #6 | exon 14 -16_2972del47pb | 116771833 | 116771879 | 81 | Female | Never smoker | ADC | - | |
| #7 | exon 14 -39_-6del34pb | 116771810 | 116771843 | 60 | Female | Never smoker | ADC | - | |
| #8 | c3082g>a; | 116771987 | 116771987 | 63 | Male | Current | ADC | - | |
| #11 | exon 14 -55_-54insCT | 116771796 | 116771797 | 39 | Male | Current | ADC | - | |
| #12 | exon 14 -55_-54insCT | 116771796 | 116771797 | 77 | Male | African | Current | ADC | - |
SC: sarcomatoid carcinoma; ADC: adenocarcinoma
*cDNA according to COSMIC nomenclature
** gDNA according to www.genome.ucsc.edu (Dec2013) nomenclature