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. 2017 Apr 15;8(25):40486–40500. doi: 10.18632/oncotarget.17119

Figure 4. IDO1 deficiency elevated the expressions of TDO and GCN2 kinase during liver fibrosis.

Figure 4

(A) LC-MS/MS analysis to detect the concentrations of TRP and KYN in liver tissues of WT and IDO1–/– mice. (B) Quantitative real-time PCR analysis to detect TDO mRNA in the liver tissues of WT and IDO1–/– mice. (C) and (D) Western blot analysis of the expression of TDO and GCN2 kinase in the livers of WT and IDO1–/– mice. (E) Immunofluorescence analysis to detect the expression of CD8a in the livers of WT and IDO1–/– mice. The data are presented as the means ± SEM (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).