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. 2016 Dec 14;66(8):1496–1506. doi: 10.1136/gutjnl-2016-312734

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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Representations of the targeted DNA sequencing (targeted-seq) for mammalian target of rapamycin (mTOR) pathway-related genes in hepatocellular carcinoma (HCC) discovery cohort. (A) A total of 95 HBV-associated human HCC tumour samples were subjected to targeted-seq for mTOR pathway-related genes. Sixty-nine HCC samples were found to carry at least one mTOR-related mutation. Among the 81 mTOR-related genes being screened, 25 were found to be recurrently mutated in more than one sample, while 22 of them were singleton. The mutant genes were ranked and listed accordingly to their frequency. (B) Schematic diagram visualising the mutants listed in (A) to illustrate their implications in mTOR-related signalling. TSC, tuberous sclerosis complex.