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. 1982;1(4):513–516. doi: 10.1002/j.1460-2075.1982.tb01200.x

Low rate of procollagen conversion in dermatosparactic sheep fibroblasts is paralleled by increased synthesis of type I and type III collagens.

M Wiestner, H Rohde, O Helle, T Krieg, R Timpl, P K Müller
PMCID: PMC553077  PMID: 7188350

Abstract

Dermatosparaxis is a genetic defect found in humans and animals, which affects the conversion of procollagen to collagen and aminopropeptides . Under cell culture conditions a reduction of the release of aminopropeptides is paralleled by an increased synthesis of collagens type I and III. This fact provides further evidence for a regulatory involvement of aminopropeptides in the biosynthesis of collagen.

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Selected References

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