Table 2.
Variables associated with the change in total and lean muscle area with 96 weeks of ART
| Total Muscle Area | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| Coef | SE | p-value | Coef | SE | P-value | |
| Change in Oblique/Transverse Abdominal Total Area | ||||||
| BMI (baseline) | −0.11 | 0.06 | 0.04 | |||
| Change in BMI | 0.42 | 0.11 | 0.0001 | 0.38 | 0.12 | 0.001 |
| CD4 >200 cells (baseline) | −1.22 | 0.59 | 0.04 | |||
| Change in Rectus Total Area | ||||||
| Change in BMI | 0.28 | 0.04 | <0.0001 | 0.25 | 0.04 | <0.0001 |
| CD4 >200 cells (baseline) | −0.90 | 0.21 | <0.0001 | −0.40 | 0.20 | 0.05 |
| Triglycerides (baseline)* | 0.03 | 0.01 | 0.002 | 0.02 | 0.01 | 0.02 |
| Change in Psoas Total Area | ||||||
| BMI (baseline) | −0.07 | 0.03 | 0.009 | −0.05 | 0.02 | 0.03 |
| Change in BMI | 0.41 | 0.05 | <0.0001 | 0.39 | 0.05 | <0.0001 |
| CD4 >200 cells (baseline) | −0.87 | 0.29 | 0.003 | |||
| Triglycerides (baseline)* | 0.03 | 0.01 | 0.02 | 0.02 | 0.01 | 0.05 |
| Change in Spinalis Total Area | ||||||
| Change in BMI | 0.26 | 0.09 | 0.003 | 0.22 | 0.09 | 0.02 |
| CD4 >200 cells (baseline) | −1.02 | 0.45 | 0.03 | |||
| Smoking | 0.82 | 0.42 | 0.05 | 0.90 | 0.41 | 0.03 |
| Lean Muscle Area | Univariate | Multivariate | ||||
| Coef | SE | p-value | Coef | SE | P-value | |
| Change in Oblique/Transverse Abdominal Lean Area | ||||||
| Change in Triglycerides | −0.06 | 0.03 | 0.04 | |||
| Change in Rectus Lean Area | ||||||
| Age | −0.02 | 0.01 | 0.05 | −0.02 | 0.01 | 0.009 |
| Change in BMI | 0.18 | 0.04 | <0.0001 | 0.16 | 0.04 | 0.0003 |
| CD4 >200 cells (baseline) | −0.71 | 0.22 | 0.002 | |||
| Triglycerides (baseline)* | 0.02 | 0.01 | 0.02 | 0.02 | 0.01 | 0.03 |
| Change in Psoas Lean Area | ||||||
| Female | −0.68 | 0.38 | 0.07 | |||
| Race/Ethnicity (ref: white) | ||||||
| Black | 0.38 | 0.27 | 0.17 | |||
| Hispanic | 0.61 | 0.30 | 0.04 | |||
| Other | −0.34 | 0.54 | 0.52 | |||
| BMI (baseline) | −0.05 | 0.02 | 0.03 | |||
| Change in BMI | 0.35 | 0.04 | <0.0001 | 0.30 | 0.05 | <0.0001 |
| CD4 >200 cells (baseline) | −1.00 | 0.25 | <0.0001 | |||
| Triglycerides (baseline)* | 0.04 | 0.01 | 0.001 | 0.03 | 0.01 | 0.003 |
| Change in Spinalis Lean Area | ||||||
| Age | −0.05 | 0.02 | 0.02 | −0.04 | 0.02 | 0.03 |
| BMI (baseline) | −0.08 | 0.04 | 0.06 | |||
| CD4 >200 cells (baseline) | −1.10 | 0.46 | 0.02 | −0.89 | 0.47 | 0.05 |
| Triglycerides (baseline)* | 0.03 | 0.02 | 0.10 | |||
| Smoking | 0.81 | 0.43 | 0.06 | |||
Univariate models included age, female, race/ethnicity, hepatitis C, BMI, change in BMI, CD4 (baseline) >200 cells/μL, change in CD4 count, protease inhibitor (vs integrase strand transfer inhibitor), triglycerides, change in triglycerides; only variables with p<0.10 were included in the multivariate analyses and shown above;
*
per change by 10 units
BMI, body mass index