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. 1987 Feb;6(2):485–491. doi: 10.1002/j.1460-2075.1987.tb04779.x

A malaria protein exported into a new compartment within the host erythrocyte.

D Simmons, G Woollett, M Bergin-Cartwright, D Kay, J Scaife
PMCID: PMC553420  PMID: 2438130

Abstract

A Plasmodium falciparum protein which is exported into a new compartment in the host erythrocyte has been located. This protein, exp-1, has a variable region recognized by a monoclonal antibody. Naturally occurring mutants of this region have been characterized. All mutants studied so far have the same A----G transition abolishing the target for the antibody. The exp-1 gene has a complex structure containing two introns. It is highly conserved in five independent, genetically defined parasite lines, suggesting that exp-1 has an important function. We discuss the possible role of exp-1 in P. falciparum infections.

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Selected References

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