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. 1987 Apr;6(4):933–938. doi: 10.1002/j.1460-2075.1987.tb04841.x

Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets.

J A Garcia-Sanz, G Plaetinck, F Velotti, D Masson, J Tschopp, H R MacDonald, M Nabholz
PMCID: PMC553485  PMID: 3297674

Abstract

We show that among the subsets of peripheral T lymphocytes (Lyt2+ L3T4- and L3T4+ Lyt2- cells) activated in short-term cultures by stimulation with H-2 incompatible leukocytes 97% of the cytolytic activity and all detectable perforin activity resides in the Lyt2+ cells. But both populations contain approximately equal amounts of a serine protease, granzyme A, the expression of which was previously thought to be restricted to cytolytic T lymphocytes.

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Selected References

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