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. 1987 Jul;6(7):1891–1897. doi: 10.1002/j.1460-2075.1987.tb02448.x

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

K Suzuki 1, H Kusumoto 1, Y Deyashiki 1, J Nishioka 1, I Maruyama 1, M Zushi 1, S Kawahara 1, G Honda 1, S Yamamoto 1, S Horiguchi 1
PMCID: PMC553573  PMID: 2820710

Abstract

We have deduced the entire 575-amino acid sequence of the human thrombomodulin precursor from cDNA clones. The precursor starts with an 18-residue signal peptide domain, followed by the NH2-terminal domain, a domain with six epidermal growth factor-like structures, an O-glycosylation site-rich domain, a 24-residue transmembrane domain and a cytoplasmic domain. Simian COS cells transfected with the expression vector pSV2 containing thrombomodulin cDNA synthesized immunoreactive and functionally active thrombomodulin.

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Selected References

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