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. 1987 Sep;6(9):2693–2698. doi: 10.1002/j.1460-2075.1987.tb02561.x

Human CSF-1: gene structure and alternative splicing of mRNA precursors.

M B Ladner 1, G A Martin 1, J A Noble 1, D M Nikoloff 1, R Tal 1, E S Kawasaki 1, T J White 1
PMCID: PMC553691  PMID: 3500041

Abstract

Bone marrow progenitor cells differentiate into mononuclear phagocytes in the presence of colony stimulating factor-1 (CSF-1). Characterization of the human CSF-1 gene shows that it contains 10 exons and 9 introns, which span 20 kb. Analysis of multiple CSF-1 transcripts demonstrates that alternate use of exon 6 splice acceptor sites and 3' noncoding sequence exons occurs. These alternatively spliced transcripts can encode either a 224 or a 522 amino acid CSF-1. Implications of differential splicing for the production and function of CSF-1 are discussed.

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Selected References

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