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. 1987 Nov;6(11):3379–3384. doi: 10.1002/j.1460-2075.1987.tb02660.x

Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection.

H Shida 1, T Tochikura 1, T Sato 1, T Konno 1, K Hirayoshi 1, M Seki 1, Y Ito 1, M Hatanaka 1, Y Hinuma 1, M Sugimoto 1, et al.
PMCID: PMC553794  PMID: 2828027

Abstract

The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV-I in rabbits and had a protective effect against HTLV-I infection.

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