Table 3.

Investigation of risk factors for stroke, New York State women with preeclampsia, matched on severity of preeclampsia.

Risk factors: multivariable analysis		All cases	Mild cases only	Severe cases only
		Odds ratio (95% CI)	Odds ratio (95% CI)	Odds ratio (95% CI)
Chronic hypertension	Unadjusted	4.8 (2.8–8.3)	3.3 (1.6–6.5)	8.6 (3.4–21.7)
	Adjusted	4.2 (2.4–7.4)	3.0 (1.4–6.3)	8.4 (3.1–22.5)
Infection present on admission	Unadjusted	2.8 (1.6–4.7)	4.3 (1.7–10.6)	2.1 (1.1–4.1)
	Adjusted	2.6 (1.4–4.6)	4.5 (1.6–12.6)	1.9* (0.9–4.0)
Prothrombotic statea	Unadjusted	3.6 (2.0–6.5)	n/a	6.1 (3.1–12.2)
	Adjusted	2.9 (1.3–6.4)	n/a	6.6 (2.5–17.5)
Coagulopathyb	Unadjusted	2.8 1.7–4.7	n/a	3.0 (1.7–5.4)
	Adjusted	1.5 (0.8–3.1)	n/a	1.3 (0.5–2.9)
Obesity	Unadjusted	n/a	9.0 (1.8–44.6)	n/a
	Adjusted	n/a	4.9 (0.9–26.5)	n/a
Heart diseasec	Unadjusted	4.5 (1.3–15.9)	n/a	3.8 (1.0–14.0)
	Adjusted	2.1 0.5–9.9	n/a	1.0 (0.2–5.4)
Migraine	Unadjusted	3.6 (1.1–11.8)	n/a	n/a
	Adjusted	3.6 (0.9–14.5)	n/a	n/a
Multiple gestation	Unadjusted	0.3 (0.1–0.8)	n/a	0.3 (0.1–0.9)
	Adjusted	0.2 (0.1–0.9)	n/a	0.2 (0.04–0.7)
Multigravida	Unadjusted	0.5 (0.3–0.7)	n/a	0.3 (0.2–0.5)
	Adjusted	0.6 (0.4–0.9)	n/a	0.3 (0.2–0.6)

^aIncludes primary hypercoagulable state, history of deep vein thrombosis or pulmonary embolism, systemic lupus erythematosis, sickle cell disease.

^bIncludes bleeding diatheses and thrombocytopenia.

^cIncludes congenital, valvular, and ischemic heart disease, and congestive heart failure.

See Supplemental Table II for complete details of diagnostic codes.