Volume 308, April 15, 2015
Volume 77, April 1, 2015
Pages F809–F821. Herak-Kramberger CM, Breljak D, Ljubojević M, Matokanović M, Lovrić M, Rogić D, Brzica H, Vrhovac I, Karaica D, Micek V, Ivković Dupor J, Brown D, Sabolić I. Sex-dependent expression of water channel AQP1 along the rat nephron. Am J Physiol Renal Physiol 308: F809–F821, 2015. First published February 5, 2015; doi:10.1152/ajprenal.00368.2014.—On p. F818, Table 3 was printed incorrectly. The correct version of Table 3 and its legend appear below.
Table 3.
Various parameters in intact adult male and female rats
| Fasted |
Nonfasted |
|||
|---|---|---|---|---|
| Parameters | Males | Females | Males | Females |
| Body mass, g | 314 ± 3 | 192 ± 2* | 345 ± 3 | 211 ± 3† |
| Kidney mass, g | N.D. | N.D. | 2.28 ± 0.05 | 1.40 ± 0.04† |
| Kidney mass index, mg/g body mass | N.D. | N.D. | 6.59 ± 0.16 | 6.63 ± 0.12 |
| Water consumption, ml/kg body mass per day | 69 ± 12.9 | 131 ± 25.1* | 80 ± 4.4 | 108 ± 10.4† |
| Food consumption, g/kg body mass per day | N.A. | N.A. | 59 ± 3.1 | 76 ± 5.3† |
| Plasma creatinine, μmol/l | N.D. | N.D. | 26.4 ± 0.62 | 26.8 ± 1.42 |
| Urine protein, mg/kg body mass per day | 32 ± 3.1 | 3.1. ± 0.4* | N.D. | N.D. |
| Urine creatinine, mmol/l | 5.57 ± 1.04 | 3.18 ± 0.61 | 7.90 ± 0.69 | 5.26 ± 0.71†‡ |
| GFR, ml·min−1·kg−1 body mass | 8.38 ± 0.27§ | 8.54 ± 0.36§ | 9.78 ± 0.66 | 8.32 ± 0.53 |
| Urine flow, ml/kg body mass per day | 73 ± 10.3 | 135 ± 21.1* | 49 ± 3.8‡ | 67 ± 7.2†‡ |
| Urine osmolality, mosmol/kgH2O | 691 ± 112 | 500 ± 88 | 1529 ± 104‡ | 1352 ± 131‡ |
Values are means ± SE. The same animals (n = 10 in each group) underwent 24-h urine collection in metabolic cages in the absence (fasted; age = 12 wk) and presence (nonfasted; age = 13 wk) of pelleted food. Statistically significant difference (t-test; P < 0.05) was observed in comparison with fasted
or nonfasted
males, or in comparison with the same sex in fasted animals
. Other relations are not significant.
Because blood creatinine is a fairly stable parameter in healthy animals, and fasted and nonfasted rats exhibit similar blood creatinine (1), glomerular filtration rate (GFR, creatinine clearance) in fasted animals was calculated using the data for urine creatinine from fasted animals and plasma creatinine from nonfasted animals. Urine protein in nonfasted animals was not measured because the collected urine was variously contaminated with the food particles. The ionic content in these particles may have also contributed with unknown extent to the level and variability of urine osmolality in nonfasted animals.
N.D., not determined; N.A., not applied.
