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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Cell. 2017 Jun 15;169(7):1240–1248.e23. doi: 10.1016/j.cell.2017.05.042

Figure 5. Semi-synthesis, synthesis, and analysis of PUM derivatives.

Figure 5

(A) Semi-synthesis of PUM derivatives lacking PUM N-hydroxy group (1), having alterations of PUM glutaminyl sidechain (2–4), or having alterations of PUM guanidinyl sidechain (5–6). (B) Synthesis of PUM derivative lacking PUM N-hydroxy group (1). (C–D) RNAP inhibitory activities and antibacterial activities of PUM derivatives.