Table 4. Multivariate Cox analysis of relapse-free and overall survival for TIAM1 variant, MYCN amplification and age at diagnosis.

Variables	Multivariate Analysis
	Relapse-free survival			Overall survival
	HR	95% CI	p	HR	95% CI	p
*Age	1.017	1.008-1.025	0.0002	1.010	1.001-1.018	0.022
TIAM1 variant
No	1.000	0.025-0.833	0.021	1.000	0.028-0.206	0.006
Yes	0.222			0.083
MYCN amplification
No	1.000	0.723-2.514	0.321	1.000	1.368-5.029	0.004
Yes	1.375			2.623

Abbreviations: HR, Hazard Ratio; CI, confidence interval

*Age was consider as continuous variable measured in months