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The distribution of significantly dysregulated circRNAs [(A) Upregulated and (B) downregulated circRNAs] and Validation of top 10 upregulated and downregulated circRNAs by qRT-PCR [(C) qRT-PCR assays verified 3 upregulated and (D) 3 downregulated circRNAs. The relative expression of each circRNA was normalized to its mean expression value in adjacent normal tissues, respectively. Data presented as mean ± SE. *P < 0.05, **P < 0.01].
