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. 2017 Apr 21;8(28):45643–45655. doi: 10.18632/oncotarget.17314

Figure 4. JQ1 induced apoptosis in U87M cells, the effect was attenuated by knocking down HEXIM1.

Figure 4

(A) U87M (mock and HEXIM1 knock down) cells were treated with JQ1 alone or combine with ubenimex at a dose of 0.5 mg/ml for 16 h. We used fluorescence microscopy to examine DNA damage and cell death. The dead cells (red) per field determined by acridine orange staining are shown. (B) Western Bolt of caspase3 (c-capase3:cleaved caspase3; P-caspase3:pro-caspase3)showed the same trend of JQ1 or JQ1+unbenimex induced apoptosis.* P<0.05. Data are expressed as the mean ± standard deviation of 3 independent experiments.