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. 2017 Apr 24;8(28):45710–45724. doi: 10.18632/oncotarget.17391

Figure 2. DNA methylation levels of the six CpG sites in the S100A15 gene promoter and exon 1 regions with respect to the clinical lung adenocarcinoma (AC) specimens and lung cancer cell lines.

Figure 2

DNA methylation levels of (A) -423 CpG site, (B) -412, and (C) -248 CpG sites were all decreased in 37 lung AC patients with distant metastasis versus 14 lung AC patients without distant metastasis. (D) Poorer one-year overall survival in lung AC patients with low DNA methylation levels (80%) over -423 CpG site of the S100A15 promoter as compared with those with high methylation levels. DNA methylation levels over (E) -412 CpG, (F) -248, and (G) -56 CpG sites of the S100A15 promoter, as well as (H) + 21 CpG site of the S100A15 exon 1 region were all decreased in CL1-5 cell line with high metastasis property versus that in the CL1-0 cell line with low metastasis property. (I) Representative pyrograms of the -583 CpG, -423 CpG, and -412 CpG sites in the S100A15 promoter region. (J) Representative pyrogrms of the -248, -56, and +21 CpG sites of the S100A15 gene.