Table 3. Two-step multivariate analysis of prognostic factors for 1289 patients.
| Characteristics | Multivariate analysis step 1 a | Multivariate analysis step 2 B | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p | HR | 95%CI | p | |
| Age | 0.000 | 0.000 | ||||
| ≤ 60 years | ||||||
| >60 years | 1.311 | 1.148-1.498 | 1.301 | 1.139-1.485 | ||
| Tumor location | 0.000 | 0.000 | ||||
| Entire | ||||||
| Lower 1/3 | 0.679 | 0.523-0.881 | 0.683 | 0.527-0.886 | ||
| Middle 1/3 | 0.679 | 0.509-0.906 | 0.684 | 0.514-0.911 | ||
| Upper 1/3 | 1.037 | 0.772-1.393 | 1.057 | 0.789-1.416 | ||
| UICC/AJCC pT stage | 0.000 | |||||
| pT3 | ||||||
| pT4a | 1.549 | 1.350-1.777 | ||||
| pT4b | 1.728 | 1.109-2.693 | ||||
| sT stage | 0.000 | |||||
| sT3 | ||||||
| sT4a | 0.849 | 0.697-1035 | ||||
| sT4b | 1.322 | 1.079-1.619 | ||||
| UICC/AJCC pN stage | 0.000 | 0.000 | ||||
| pN0 | ||||||
| pN1 | 1.489 | 1.213-1.827 | 1.477 | 1.204-1.812 | ||
| pN2 | 1.752 | 1.434-2.140 | 1.725 | 1.413-2.105 | ||
| pN3 | 2.597 | 2.141-3.149 | 2.569 | 2.120-3.114 | ||
| Lymphovascular invasion | 0.002 | 0.002 | ||||
| Negative | ||||||
| Positive | 1.258 | 1.088-1.454 | 1.256 | 1.087-1.451 | ||
| Borrmann type | 0.004 | 0.004 | ||||
| Borrmann 1 | ||||||
| Borrmann 2 | 0.790 | 0.497-1.257 | 0.801 | 0.504-1.272 | ||
| Borrmann 3 | 1.032 | 0.665-1.601 | 1.048 | 0.676-1.623 | ||
| Borrmann 4 | 1.355 | 0.836-2.194 | 1.371 | 0.847-2.218 | ||
| Borrmann 5 | 0.900 | 0.358-2.261 | 0.919 | 0.367-2.298 | ||
| Revised pT stage | 0.000 | |||||
| rT3 | ||||||
| rT4a | 1.490 | 1.279-1.736 | ||||
| rT4b | 2.299 | 1.911-2.767 | ||||
Abbreviations: UICC, International Union Against Cancer; AJCC, American Joint Committee on Cancer; HR, hazard ratio; CI, confidence interval.
a: Step 1, with consideration of all significantly important prognostic factors in univariate analysis, except for the revised pT stage
b: Step 2, with consideration of all significantly important prognostic factors in univariate analysis, including the revised pT stage