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. 1985 Jun;4(6):1461–1465. doi: 10.1002/j.1460-2075.1985.tb03803.x

The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.

T H Rabbitts, M P Lefranc, M A Stinson, J E Sims, J Schroder, M Steinmetz, N L Spurr, E Solomon, P N Goodfellow
PMCID: PMC554368  PMID: 3875483

Abstract

We have examined the chromosomal location of human T cell-specific genes which are involved in antigen recognition and of a gene which specifically rearranges in T cells. The genes encoding both the variable and constant region segments of the T cell receptor alpha chain are found on chromosome 14 while the delta chain gene of the T cell receptor-associated T3 complex is localised to chromosome 11. Further, the two tandemly arranged T cell-specific rearranging genes, designated gamma, were mapped to chromosome 7, but apparently not closely linked to the previously mapped T cell receptor beta-chain gene. The locations of the three different genes, which undergo rearrangement in T cells, may correlate with the chromosomal breakpoints known to be involved in translocations within abnormal human T cells.

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