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. Author manuscript; available in PMC: 2018 Apr 20.
Published in final edited form as: Cell. 2017 Apr 20;169(3):381–405. doi: 10.1016/j.cell.2017.04.001

Figure 4. Akt-mediated regulation and transcriptional targets of FoxO family members.

Figure 4

A. Schematic of three FoxO family members, with the three conserved Akt phosphorylation sites denoted relative to the DNA-binding domain (DBD), nuclear localization sequence (NLS) and nuclear export sequence (NES). B. Akt-mediated phosphorylation of FoxO leads to its binding and cytosolic sequestration by 14-3-3 proteins, thereby attenuating the expression of its gene targets, a partial list of which is shown.