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. 2017 Jan 31;8(27):43915–43924. doi: 10.18632/oncotarget.14918

Figure 1. Unsupervised clustering analysis of HLA ligand source proteins represented in the immunopeptidomes of HM.

Figure 1

Peptides identified by LC-MS/MS in HLA class I ligand extracts of AML (light green, n=19), CML (dark green, n=16), CLL (red, n=35) and MM/MCL (orange/yellow, n=9/4) were mapped to their source proteins. For conserved sequences mapping to multiple proteins all protein annotations were retained. Complete linkage clustering was performed based on the Jaccard similarity coefficient of HLA ligand source proteins. A subset of source proteins shared across samples and entities with high frequencies of presentation is highlighted in the blue box; infrequent, sample/entitity-specific source proteins are highlighted in the purple box.