Table 5. Risky of death among GBM patients in relation to calendar period of diagnosis in the combined dataset (N=28933).
| Cases | Death | Age-sex adjusted | Model 1a | Model 2b | Model 3c | Model 4d | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Predictors | N | N | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI | HR | 95%CI |
| Calendar period of diagnosis | ||||||||||||
| Jan 2000-Feb 2005 (P1) | 9526 | 9278 | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Mar 2005-Apr 2009 (P2) | 8706 | 8264 | 0.82 | 0.79 - 0.84 | 0.82 | 0.79 - 0.84 | 0.82 | 0.80 - 0.85 | 0.82 | 0.80 - 0.85 | 0.82 | 0.80 - 0.85 |
| May 2009-Dec 2013 (P3) | 10701 | 7601 | 0.75 | 0.73 - 0.77 | 0.75 | 0.73 - 0.78 | 0.76 | 0.73 - 0.78 | 0.76 | 0.73 - 0.78 | 0.76 | 0.73 - 0.78 |
| Age at diagnosis group | ||||||||||||
| 20-49 | 5180 | 4022 | 1.00 | - | 1.00 | - | ||||||
| 50-59 | 7457 | 6317 | 1.50 | 1.44 - 1.56 | 1.50 | 1.44 - 1.56 | 1.49 | 1.44 - 1.56 | 1.48 | 1.43 - 1.55 | 1.49 | 1.43 - 1.55 |
| 60-69 | 8310 | 7301 | 2.01 | 1.93 - 2.09 | 2.01 | 1.94 - 2.10 | 2.02 | 1.94 - 2.10 | 1.98 | 1.90 - 2.06 | 1.98 | 1.90 - 2.06 |
| 70- | 7986 | 7503 | 3.40 | 3.26 - 3.53 | 3.36 | 3.22 - 3.50 | 3.36 | 3.23 - 3.50 | 3.09 | 2.96 - 3.22 | 3.09 | 2.96 - 3.22 |
| Sex | ||||||||||||
| Male | 17039 | 14788 | 1.00 | - | 1.00 | - | ||||||
| Female | 11894 | 10355 | 0.97 | 0.95 - 1.00 | 0.95 | 0.92 - 0.97 | 0.95 | 0.92 - 0.97 | 0.95 | 0.93 - 0.97 | 0.95 | 0.93 - 0.97 |
| Race/Ethnicity | ||||||||||||
| White | 23042 | 20301 | 1.00 | - | ||||||||
| Black | 1610 | 1366 | 1.06 | 1.01 - 1.12 | 1.06 | 1.00 - 1.12 | 1.02 | 0.96 - 1.07 | 1.02 | 0.96 - 1.08 | ||
| Hispanic | 3059 | 2515 | 0.96 | 0.92 - 1.00 | 0.95 | 0.92 - 0.99 | 0.91 | 0.87 - 0.95 | 0.92 | 0.88 - 0.96 | ||
| Others | 1222 | 961 | 0.82 | 0.77 - 0.88 | 0.81 | 0.76 - 0.87 | 0.79 | 0.74 - 0.84 | 0.79 | 0.74 - 0.84 | ||
| Marital status | ||||||||||||
| Single | 3868 | 3161 | ||||||||||
| Married | 19693 | 17107 | 0.91 | 0.87 - 0.94 | 0.91 | 0.87 - 0.94 | 0.96 | 0.92 - 1.00 | 0.96 | 0.92 - 1.00 | ||
| DWS | 5372 | 4875 | 1.10 | 1.05 - 1.15 | 1.10 | 1.05 - 1.15 | 1.13 | 1.08 - 1.18 | 1.13 | 1.08 - 1.18 | ||
| Tumor site | ||||||||||||
| Supratentorial | 22428 | 19341 | ||||||||||
| Infratentorial/NOS | 6505 | 5802 | 1.24 | 1.21 - 1.28 | 1.14 | 1.11 - 1.18 | 1.14 | 1.11 - 1.18 | ||||
| Surgery | ||||||||||||
| No surgery | 5349 | 5018 | ||||||||||
| Local excision/biopsy | 5749 | 5077 | 0.61 | 0.59 - 0.64 | 0.61 | 0.59 - 0.64 | ||||||
| Partial resection | 8237 | 7116 | 0.66 | 0.64 - 0.69 | 0.66 | 0.64 - 0.69 | ||||||
| Gross subtotal resection (GTR) | 9598 | 7932 | 0.50 | 0.48 - 0.52 | 0.50 | 0.48 - 0.52 | ||||||
| Radiation | ||||||||||||
| Untreated | 5981 | 5543 | ||||||||||
| Treated | 22952 | 19600 | 0.55 | 0.53 - 0.56 | 0.54 | 0.52 - 0.56 | ||||||
| Cancer Registries | ||||||||||||
| TCR | 4355 | 3779 | ||||||||||
| SEER | 24578 | 21364 | 1.07 | 1.03 - 1.11 | ||||||||
Abbreviation: DWS, divorced or widowed or separated; NOS, not otherwise specified; GTR, gross total resection; HR, hazard ratio; 95%CI, 95% confidence interval.
a: Model 1: Adjusted age at diagnosis, sex, race/ethnicity and marital status.
b: Model 2: Adjusted age at diagnosis, sex, race/ethnicity, marital status and tumor site.
c: Model 3: Adjusted age at diagnosis, sex, race/ethnicity, marital status, tumor site, surgery and radiation.
d: Model 4: Adjusted age at diagnosis, sex, race/ethnicity, marital status, tumor site, surgery, radiation and cancer registries.